The concept of telomeres emerged in the 1930s, when a hypothesis emerged that a characteristic structure at the ends of chromosomes was crucial for preventing their fusion. Since then, extensive research has provided increasing information, confirming their role in the aging process and the development of various diseases.
Telomeres are repeating sequences of six nucleotides (TTAGGG) that form a "t-loop" structure, also known as a cap. This structure protects the ends of chromosomes from degradation and fusion with other chromosomes. Telomere shortening with each cell division is a natural aging process at the cellular level. Telomeres protect the ends of chromosomes from initiating the DNA damage response, serving as a natural cellular shield.
Can telomere shortening be prevented?
Telosense™ is an innovative anti-wrinkle ingredient found in the Rich Cream from the Miorelaxant Magic line. It's a complex of bioactive peptides derived from hydrolyzed yeast and soy proteins, acting at the cellular and molecular levels to protect the skin from premature aging.
Mechanism of action of hydrolyzed peptides
Hydrolyzed yeast and soy peptides work at the molecular level, protecting telomeres and supporting the health and longevity of skin cells in several ways.
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They reduce oxidative stress – telomeres are sensitive to free radicals. Bioactive peptides neutralize reactive oxygen species (ROS), which accelerate telomere shortening, thereby reducing the risk of DNA damage.
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Stabilize telomere structure - they support natural telomere-binding proteins (e.g. TRF1, TRF2), keeping the ends of chromosomes in a stable t-loop structure.
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They support the activity of telomerase - an enzyme that partially regenerates telomeres and slows down their shortening.
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They strengthen DNA repair mechanisms - they stimulate the cell's natural repair processes, strengthening its ability to regenerate and slowing down aging.
Effects on the skin
Thanks to these actions, hydrolyzed yeast and soy peptides help slow down the cellular aging process, improve skin density and elasticity, help smooth wrinkles and even out skin tone, and strengthen the skin's natural protective barrier.
Hydrolyzed peptides are an ingredient of modern, advanced rejuvenating cosmetics, including the Rich cream from the Miorelaxant Magic line – ideal for mature skin requiring special protection.
Razgonova MP, Zakharenko AM, Golokhvast KS, Thanasoula M, Sarandi E, Nikolouzakis K, Fragkiadaki P, Tsoukalas D, Spandidos DA, Tsatsakis A. Telomerase and telomeres in aging theory and chronographic aging theory (Review). Mol Med Rep. 2020 Sep;22(3):1679-1694. doi: 10.3892/mmr.2020.11274. Epub 2020 Jun 25. PMID: 32705188; PMCID: PMC7411297.
Schellnegger M, Hofmann E, Carnieletto M, Kamolz LP. Unlocking longevity: the role of telomeres and their targeting interventions. Front Aging. 2024 Jan 25;5:1339317. doi: 10.3389/fragi.2024.1339317. PMID: 38333665; PMCID: PMC10850353.
Ashland. Telosense™ Biofunctional:Technical Datasheet. Ashland Specialty Ingredients, https://www.ashland.com/industries/personal-and-home-care/skin-and-sun-care/telosense-biofunctional
